Thrombophilia

Lupus Anticoagulant (LA)

Lupus Anticoagulant (also known as lupus antibody, LA, or lupus inhibitors) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Lupus anticoagulant is a misnomer as it is actually a prothrombotic agent.

Lupus Anticoagulants are considered to be a significant cause of recurrent   miscarriages and life threatening venous clots.

Lupus Anticoagulants are phospholipid “interfering” antibodies, which prolong clotting tests that are responsive to procoagulant phospholipid concentration such as APTT and dRVVT. Lupus Anticoagulants are not corrected by mixing with normal plasma but may be corrected by the addition of phospholipid.

TECHNOCLOT® LA Screen and TECHNOCLOT® LA Confirm are simplified, one-stage Dilute Russel’s Viper Venom Time (dRVVT) tests, comprising a complete screening and confirmatory system for the detection of Lupus Anticoagulant.

Lupus Anticoagulant Test is a modified activated partial thromboplastin time (aPTT) with an activator of SiO2/AI2O3 suspension and two phospholipid concentrations. The modified aPTT’s are performed with  normal plasma (free from platelet contamination), with patient plasma and with a mixture of both plasmas. From the shape of the “aPTT against plasma concentration” curve the probability of the presence of lupus inhibitor can be assessed.

LITERATURE

Lupus Anticoagulant Test

1 x 3 ml Reagent A

2 x 3 ml Reagent B

2 x 2 ml Reagent C

1 x 1 ml Lupus Inhibitor Plasma Low

REF Package Size Insert
5343005 ~ 6 tests Download Insert

TECHNOCLOT® LA Screen

Simplified screening (one-stage) dilute Russel's Viper Venom (dRVV) Test

REF Package Size MSDS Insert
5343012 5 x 2 ml Download MSDS Download Insert

TECHNOCLOT® LA Confirm

Confirmatory simplified screening (one-stage) dilute Russel's Viper Venom (dRVV) Test

REF Package Size MSDS Insert
5343016 5 x 1 ml Download MSDS Download Insert

Lupus Inhibitor Plasma (positive)

Positive Control for determination of Lupus Inhibitor.

REF Package Size MSDS Insert
5343010 2 x 1 ml Download MSDS Download Insert
5343019 5 x 1 ml Download MSDS Download Insert

Lupus Inhibitor Plasma Low (positive)

Low Positive Control for determination of Lupus Inhibitor

REF Package Size MSDS Insert
5343021 5 x 1 ml Download MSDS Download Insert

Platelet Poor Plasma (negative)

Negative Control for determination of Lupus Inhibitor.

REF Package Size MSDS Insert
5343022 5 x 1 ml Download MSDS Download Insert