Lupus Anticoagulant (LA)
Lupus Anticoagulant (also known as lupus antibody, LA, or lupus inhibitors) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Lupus anticoagulant is a misnomer as it is actually a prothrombotic agent.
Lupus Anticoagulants are considered to be a significant cause of recurrent miscarriages and life threatening venous clots.
Lupus Anticoagulants are phospholipid “interfering” antibodies, which prolong clotting tests that are responsive to procoagulant phospholipid concentration such as APTT and dRVVT. Lupus Anticoagulants are not corrected by mixing with normal plasma but may be corrected by the addition of phospholipid.
TECHNOCLOT® LA Screen and TECHNOCLOT® LA Confirm are simplified, one-stage Dilute Russel’s Viper Venom Time (dRVVT) tests, comprising a complete screening and confirmatory system for the detection of Lupus Anticoagulant.
Lupus Anticoagulant Test is a modified activated partial thromboplastin time (aPTT) with an activator of SiO2/AI2O3 suspension and two phospholipid concentrations. The modified aPTT’s are performed with normal plasma (free from platelet contamination), with patient plasma and with a mixture of both plasmas. From the shape of the “aPTT against plasma concentration” curve the probability of the presence of lupus inhibitor can be assessed.