Antibodies

Monoclonal anti t-PA antibody 2VPA, Iyophilized

IgM; half maximal binding to coated t-PA at 650 ng/mL (high affinity); reaction with free t-PA and t-PA-PAI-1 complexes; no cross-reaction with urokinase. Directed against an epitope on the light chain of t-PA away from the active site. It stimulates plasminogen activation in the presence of CNBr fragments of fibrinogen and of plasminogen activation in the absence of CNBr fragments of fibrinogen.
  

Monoclonal anti t-PA antibody 3VPA, Iyophilized

IgG₁; half maximal binding to coated t-PA at 8.5 µg/mL (high affinity); Reaction with an epitope expressed on both the finger domain and growth factor domain of t-PA. Competitive inhibition of plasminogen activation in the presence of fibrin (Ki=0.68 nM).
   

Monoclonal anti t-PA antibody 7VPA, Iyophilized

IgG₁; half maximal binding to coated t-PA at 19 µg/mL (low affinity); Reaction with an epitope expressed on kringle2. Competitive inhibition of plasminogen activation in the presence of fibrin (Ki=0.57 nM).